Learning About Tourette Syndrome

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Tourette syndrome is referenced as a neurological disorder and is characterized by repetitive involuntary movements. These recurring movements are known as tics, which can cause both sudden vocal or physical actions. This illness derives its name from French Neurologist Dr. Georges Gilles de la Tourette, who was the first to identify the condition in an elderly aristocrat. Even today, Tourette syndrome is wrongly suggested to be a behavioral deformity or a sign of nervousness. The syndrome largely affects the nervous growth of a person and often starts to develop between the ages 2 to 21 years and continues throughout life.

It is reported that around 200,000 Americans are suffering from the most chronic form of the Tourette syndrome, while there are hundreds of other cases of moderate and mild cases of vocal and motor tics. Similarly, some people who experienced worst symptoms during early teenage years claimed to have witnessed an improvement in their condition later at an older age.

Tourette Symptoms

The Tourette syndrome can be discovered during early childhood by observing significant and noticeable behaviors in the child. Tics are generally like hiccups. They are unplanned and are out of an individual’s control. But hiccups can be stopped by many of the tested and tried tricks like drinking water. However, Tourette tics can’t be controlled under any circumstance. They are experienced as an increasing tension in ones’ body known as a premonitory urge. That makes it irresistible for the person to perform a particular action. Once the tic is released, the tension decreases which relaxes one’s body and brain cells.

Tourette tics can be divided into two types namely, vocal and physical and they usually occur in a combination.

  • Motor Tics

Motors tics are described as sudden and repetitive movements. These actions involve performing a certain action in order to satisfy rising muscle tension. Motor tics are also the first type of tics to be discovered and a person must exhibit two or three such involuntary actions every day for a year to be diagnosed as a Tourette patient. Motor tics can be divided into two types that are simple tics and complex tics.  

Simple tics include actions such as facial contortion, shoulder shrugging, neck stretching and head jerking. These actions can occur independently or in a combination with each other. The more serious tics appear more prominently such as twisting, bending, touching and smelling objects. Although these twitches are physically harmless to the person, there are certainly more severe tics such as jaw clenching and biting.  These actions occur as an outburst of a suppressed frustration and are self-injurious.

  • Vocal Tics

It is generally observed that vocal tics develop after the person has experienced motor tics. Vocal or phone tics causes people to produce sounds they don’t intend to.  These vocal tics can be further classified into simple and complex levels based on their frequency and severity. Simple vocal tics largely include hooting, constantly clearing your throat, coughing, shouting and tongue clicking. While more complex tics can be traced during speech. Around 10-15% of all complex vocal tics are termed as Coprolalia, which causes a person to involuntarily speak obscene or improper words or phrases. Other such symptoms can be repeating someone’s words or anything just heard.

Causes and Diagnosis

Tourette syndrome is described as a genetic disorder but it is not contagious. This means that families with Tourette history are most likely to pass on the condition to future generations. Being a majorly neurological condition with not many developments made in the field, the exact cause of the syndrome is yet to be discovered.

According to a few research studies, Tourette syndrome is a result of imbalances in the brain chemicals namely norepinephrine dopamine, serotonin. These chemicals, collectively known as neurotransmitters, aid the nerves in communicating inside the brain by carrying signals from one cell to another. Another part of the brain called the basal ganglia, which is responsible for various body movements, also plays a role in generating tics.

With there being no specific test for Tourette syndrome, a doctor or neurologist would usually assess the family history along with medical records. A doctor would also observe the individual’s symptoms and in some cases conduct medical tests such as brain scans and blood tests.

Although Tourette syndrome can be a lifelong disorder limiting one’s control over movement, the syndrome in itself is not life-threatening. People suffering from the condition are able to live a normal life, working, studying and enjoying their time like everyone else.

 

What are Free Radicals and How to Counter Them with Antioxidants?

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Wordcloud illustration of antioxidants. Bigstock

You might have heard about the negative effects of free radicals and how antioxidants are used to remove them. However, very few of us know what free radicals are and how they work against the human body to inflict harm.

In this article, we discuss how free radicals affect our health and how we can alleviate their harmful effects with the help of antioxidants.

What are Free Radicals?

Chemical Illustration of an atom with a missing electron
Chemical Illustration of an atom with a missing electron, causing it to become a free radical. Photo: CC Wikipedia

Electrons, when not paired in their atomic orbits are highly unstable. A free radical is a name given to an atom that possesses an unpaired electron, meaning a missing electron, and subsequently, produces unstable cells that can damage our cell membranes.

 The process by which atoms lose electrons is called oxidation and this is not a healthy process for us humans (or any animal) and it can result in a variety of illnesses. When the free radicals are successful, they set off an oxidative chain reaction that can affect hundreds of millions of molecules and consequently, inhibits the cells that work to keep our bodies healthy.

Let’s see how free radicals operate.

Reactions of Free Radicals in Our Body

As mentioned. when free radicals are formed, they try to obtain electrons from different molecules, be it proteins, fats, cell membranes, or genetic molecules; in other words, they try to steal electrons from the atoms of the nutrients that work to keep us healthy. The removal of an electron from any such molecule changes its basic state and triggers an oxidative chain reaction. This phenomenon caused by free radicals is known as oxidative stress.

What is the Free Radical Theory of Aging?

According to the free radical theory of aging, organisms age because their biological cells accumulates oxidative damage of free radicals over time. Even though the debate on the authenticity of this theory is still ongoing,  research studies have agreed on the fact that oxidative stress can lead to this degeneration.

For instance arthritis, heart problems, Alzheimer’s disease, hypertension, Parkinson’s disease, muscular dystrophy, and many other health complications can be caused by the prevalence of free radicals.

According to the free radical theory of aging, if oxidative destruction caused by free radicals can be capped, then it can provide longevity to any living being.

So, have we found the fountain of youth?  Most likely not, but have we found a way to keep us healthy to the point that we may live longer? Absolutely.

Sources of Free Radicals

To counter the effects of free radicals, it is imperative to know how they originate. They can be produced within the body or we get exposed to them from external sources. Whatever the case, knowing where they come from, holds the key to getting rid of them!

Internal Sources of Free Radicals

 

      • The human body needs the energy to survive and grow. This energy comes from breaking down the food that we eat into ATP molecules with the help of oxygen. This chemical reaction also produces free radicals as a byproduct.
      • Free radicals are also produced when the body undergoes severe stress levels or inflammation (the process by which the body moves to protect itself against harm; e.g. cutting yourself while shaving – white blood cells run to protect from the injury).
      • There are a host of other ways that free radicals can occur. Our job is to keep them at bay by exercising, eating the right foods, and avoiding unnecessary stress.

Sources of Free Radicals

 

nicotine cigarettes in ashtray
Do you really want this kind of nicotine in your body? Photo: Pxhere

What should we stay away from? Let’s start with fried foods. Not only are they bad for your weight, but how they are cooked causes free radicals to develop. 

There are lots of harmful external resources that can expose the human body to free radicals as well, as indicated below.

  • Industrial pollution (including chemicals and smoke)
  • Radiation
  • Pesticides
  • Toxic Metals
  • Cigarette Smoke

It is practically impossible to get rid of external free radicals altogether since they are all around us, in the air we breathe and in the food and water we consume. The best practice is to try and minimize their levels in your body.

How to do this? Read on for more information.

Antioxidants: Crusaders Against Free Radicals

 

Illustration of how Antioxidant Works Against Free Radicals
Antioxidant donates a missing electron to a Free radical. Now all electrons are paired. Photo: Bigstock

As the name suggests, antioxidants are substances that inhibit the process of oxidation. Introducing antioxidants in the body means that you can stop the oxidative process, officially called oxidative stress.

How Do Antioxidants Inhibit Free Radicals?

Antioxidants stop free radicals from inflicting damage by donating the electron they are looking for.

Like free radicals, some antioxidants are produced within the body, while others can be consumed through dietary products and supplements. Fruits and vegetables are some of the best sources of antioxidants, but there are other foods as well.

There are several other antioxidants, which although not as vital as the ones mentioned above are also necessary for combating the negative effects of free radicals.

    • Lycopene
    • Vitamin C and E
    • Anthocyanins
    • Selenium
    • Polyphenols
    • Curcuminoids

What Foods Contain the Highest Amounts of Antioxidants?

Assortment of Vegetables
Eating fruits and vegetables is one of the best ways to gain antioxidants. Photo: Maxpixel

Coffee has been known to contain high levels of antioxidants, but here’s a short list of some other foods that contain antioxidants:

  • Green Tea
  • Dark chocolate
  • Blueberries
  • Broccoli
  • Potatoes

Making Sense of It All

Antioxidants are free radical killers. They reduce the formation of ions or free radicals and work towards donating an electron. Once the cell has its missing entity – the electron, the free radical is neutralized. The idea is to maintain the availability of antioxidants by eating the right foods and avoiding external resources such as smoking and alcohol.

In general, you can make sure that your body has access to antioxidants by adjusting your dietary habits around fruits and vegetables. Plant-based foods are one of the richest sources of micronutrients and antioxidants, and both of these substances are necessary to rid the body of free radicals.

Bottom Line

Cells that have missing electrons in the body are bad news. If these guys are allowed to accumulate, they can become very harmful to us. There are many ways that oxidation can occur within our bodies. But there is a hero – Antioxidants – molecules that search for and neutralize these free radicals. We can obtain antioxidants by consuming foods and drinks rich in antioxidants daily.

Increased Physical Activity is Linked to Improved Cognitive Functions


”elderly
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According to a recent study from the University of Sydney, the gradual increment of muscle-strengthening activities can lead to better cognitive function. This analysis is based on a trial that includes the Study of Mental and Resistance Training (SMART) done on patients aged between 55-58 years old with mild cognitive impairment (MCI). People with MCI are more vulnerable to develop dementia and Alzheimer’s disease.  

MCL is a strong indication that individuals will suffer from Alzheimer’s disease in the near future and nearly 80% of the elderly people suffering from MCI develop Alzheimer’s in the course of six years.

Significance of the Study

Results of the study are very significant considering increased cases of dementia and Alzheimer’s disease among the aging demographics. According to the annual report of Alzheimer’s Disease International, 47 million people are suffering from dementia worldwide and this number will be increased threefold by the mid of the century. Predicted figures for the US suggest that there will be 13.8 million citizens affected by Alzheimer’s by 2050.

It is also worth mentioning that the healthcare cost for patients with dementia is very high, making it imperative to find other preventive measures to increase the quality of a patient’s life. Therefore, finding a relation between increased physical activity and improved cognitive function will certainly help in alleviating the intense effects of these debilitating diseases.

This study examined 100 senior adults with MCI. Patients with MCI face slight cognitive difficulties that are not detrimental enough to hinder daily routines. These patients were divided into four sub-groups and assigned four types of activities:

  • Resistance exercise activity
  • Placebo resistance exercise
  • Cognitive training
  • Placebo cognitive training

Cognitive and both of the placebo activities did not result in cognitive improvement. However, the study concludes that there is a direct relationship between improved muscle strength and improved cognitive functions. Some previous studies have also shown a proportional link between increased physical activity and muscle strength. But this research assisted by the SMART trial has provided useful details about the exercises that can help in improving brain function. The trial lasted for six months in which the participants attended weightlifting sessions twice a week. With maintaining their peak strength at 80%, the weights used in the exercise were regularly increased, as their muscles got stronger with time.

According to the doctor leading the research team, including resistance exercise in the schedule of the elderly can result in a healthier aging population. However, it can only be effective if it is done on regular basis and integrated as a part of a lifestyle.

Exercise Assists Physiological Process Necessary to Avoid Cognitive Impairment

Even before the SMART trial research, studies have proven that physical exercise can help in improving brain function by assisting different physiological processes. Exercise helps in improving cardiovascular health and glucose regulation in the body and both in their optimal form are necessary to avoid the risk of cognitive diseases. Exercise can also help in even improving the brain functions such as selective attention, multitasking and planning.

Exercise can Increase the Size of Certain Brain Areas

Hippocampus is that area of the brain associated with the processing and retention of memories and especially long-term memories. With aging, it starts to shrink in size leading to cognitive impairment. Aerobic exercises have a proven role in increasing the size of the anterior part of the hippocampus. The fractional increment in size can improve the spatial memory of an individual.

What’s Next in the Research Line?

According to the researchers of a SMART trial study, it is still unclear that whether resistance exercises are directly influencing and decelerating the deteriorating effects of old age, or whether they are commanding some bodily functions that are helping the cognition improvement. New researchers will try to find the exact relation of increased muscle strength with cognitive activity. They will also study the effects of muscle strength on size and activity of certain brain areas.

All the researchers and studies that we have discussed in this article share the same conclusion that a healthy lifestyle with increased physical activity can reward aging people with a vigorous and active mindless prone to old age cognitive diseases.